Selected Primary Research Articles
Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling.
Chang NP, DaPrano EM, Evans WR, Nissenbaum M, McCourt M, Alzate D, Lindman M, Chou TW, Atkins C, Kusnecov AW, Huda R, and Daniels BP. (2023) BioRxiv. doi: 10.1101/2023.07.21.550097 (PDF)
RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection.
Lindman M, Angel JP, Estevez I, Chang NP, Chou TW, McCourt M, Atkins C, and Daniels BP. (2023) BioRxiv. doi: 10.1101.2023.01.23.525284 (Accepted at Plos Pathogens, in press) (PDF)
Zika virus-induced TNFα signaling dysregulates expression of neurologic genes associated with psychiatric disorders.
Kung PL, Chou TW, Lindman M, Chang NP, Buckley BD, Atkins C, and Daniels BP. (2022) Journal of Neuroinflammation 19:100. doi.org/10.1186/s12974-022-02460-8 (PDF)
Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB.
Chou TW*, Chang NP*, Krishnagiri M, Patel AP, Lindman M, Angel JP, Kung P, Atkins C, and Daniels BP. (2021) Cell Death & Disease. 12:756. doi:10.1038/s41419-021-04049-0 (*Equal contribution) (PDF)
The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to promote an antiviral metabolic state in neurons.
Daniels BP, Kofman SB, Smith JR, Norris GT, Snyder AG, Kolb JP, Gao X, Locasale JW, Martinez J, Gale Jr. M, Loo YM, and Oberst A. (2019) Immunity. 50:64-76. doi:10.1016/j.immuni.2018.11.017 (PDF)
Highlight: Evans AS and Coyne CB (2019) RIPK3: Beyond Necroptosis. Immunity.
Highlight: Minton K (2017) Neuronal itaconate restricts viral infection. Nature Reviews Immunology
RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation.
Daniels BP, Snyder AG, Olsen TM, Orozco S, Oguin III TH, Tait SWG, Martinez J, Gale Jr. M, Loo YM, and Oberst A. (2017) Cell. 169:301-313. doi:10.1016/j.cell.2017.03.011 (PDF)
Highlight: Ragan KB and Upton JW (2017) Neurons loosen the gRIP of death. Nature Microbiology.
Highlight: Gilley RP and Kaiser WJ (2017) A RIPtide protects neurons from infection. Cell Host & Microbe.
Highlight: Tummers B and Green DR (2017) RIPped for neuroinflammation. Cell Research.
Regional astrocyte interferon signaling restricts pathogenesis during neurotropic viral infection.
Daniels BP, Jujjavarapu H, Durrant DM, Williams JL, Green RR, Lazear HM, Gale Jr. M, Diamond MS, and Klein RS. (2017) Journal of Clinical Investigation. 127(3):843-856. doi:10.1172/JCI88720 (PDF)
Media: Discussed on This Week in Virology Podcast Episode 428 (discussion starts at 33:30)
Interferon-λ restricts West Nile virus neuroinvasion by enhancing integrity of the blood-brain barrier.
Lazear HM*, Daniels BP*, Pinto AK, Huang AC, Vick SC, Gale Jr. M, Klein RS, & Diamond MS. (2015) Science Translational Medicine. 7(284):284ra59. doi:10.1126/scitranslmed.aaa4304
(*Equal contribution) (PDF)
Highlight: Best SM. Is the third interferon a charm? Science Translational Medicine.
Press Coverage: Neurology Today - A new form of interferon may keep West Nile virus from getting into the brain
Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals.
Daniels BP, Holman DW, Cruz-Oregno L, Jujjavarapu H, Durrant DM & Klein RS. (2014) . mBio. 5(5):e01476-14. doi:10.1128/mBio.01476-14 (PDF)
Enhanced S1PR2 expression underlies female CNS autoimmunity susceptibility.
Cruz-Orengo L*, Daniels BP*, Dorsey D, Basak SA, Grajales-Reyes JG, McCandless EE, Piccio L, Schmidt RE, Cross AH, Crosby SD, & Klein RS. (2014) Journal of Clinical Investigation. 124(6):2571-2584. doi:10.1172/JCI73408 (*Equal contribution) (PDF)
Press Coverage: BBC - Multiple sclerosis discovery may explain gender gap
Press Coverage: Huffington Post - Is this why multiple sclerosis is more common in women?
Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier.
Daniels BP, Cruz-Orengo L, Paseika TJ, Couraud PO, Romero IA, Weksler B, Cooper J, Doering TL, & Klein RS. (2013) Journal of Neuroscience Methods. 212(1):173-179. doi:10.1016/j.jneumeth.2012.10.001 (PDF)
Selected Reviews and Commentaries
Paradoxical roles for programmed cell death signaling during viral infection of the central nervous system.
Angel JP and Daniels BP. (2022) Current Opinion in Neurobiology 77.102629 https://doi.org/10.1016/j.conb.2022.102629 (PDF)
Outcomes of RIP kinase signaling during neuroinvasive viral infection.
Daniels BP and Oberst A. (2020) Current Topics in Microbiology and Immunology. Springer, Berlin, Heidelberg. doi: 10.1007/82_2020_204 (PDF)
Knocking on closed doors: Host interferons dynamically regulate blood-brain barrier function during viral infections of the central nervous system.
Daniels BP and Klein RS. (2015) PLOS Pathogens. 11(9):e1005096. doi:10.1371/journal.ppat.1005096 (PDF)
Viral sensing at the blood-brain barrier: new roles for innate immunity at the CNS vasculature.
Daniels BP and Klein RS. (2015) Clinical Pharmacology and Therapeutics. 97(4):372-79 (PDF)